Conference call and web cast scheduled for 9:00 a.m. eastern time

ArQule, Inc. (NASDAQ: ARQL) today announced that it will report its financial results for the first quarter of 2008 in a press release to be issued on Monday, May 12, 2008 at 7:00 a.m. eastern time. The Company will host a conference call and web cast to discuss these results at 9:00 a.m. eastern time on that day.

A replay of the conference call will be available for seven days following the call and can be accessed by dialing toll-free 888-286-8010 and outside the U.S. 617-801-6888. The access code is 25146187.

You may use the following link to pre-register and view important information about this conference call. Pre-registering is not mandatory, but it will provide you immediate entry into the call and will facilitate the timely start of the call. You may pre-register at any time, including up to and after the call start time. To pre-register, go to: http://www.theconferencingservice.com/prereg/key.process?key=PFP4XJHG7

About ArQule

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum products and research programs are focused on key biological processes that are central to cancer. ArQule’s clinical-stage products consist of ARQ 197, an inhibitor of the c-Met receptor tyrosine kinase, and ARQ 501, an activator of the cell’s DNA damage response mechanism mediated by the E2F-1 transcription factor. The Company’s most advanced pre-clinical development programs are focused on ARQ 761, a second-generation E2F-1 activator, as well as compounds that inhibit the Eg5 kinesin spindle protein and the B-RAF kinase. ArQule’s discovery efforts are focused on the identification of novel kinase inhibitors that are potent, selective and do not compete with ATP (adenosine triphosphate), an energy source for cells.

ArQule, Inc.
William B. Boni, 781-994-0300
VP, Investor Relations/Corp. Communications
www.ArQule.com