Findings Demonstrate Statistically Significant Improvements in Skin Tightening and Tissue Shrinkage;

Data to be Presented at 2009 American Society for Laser Medicine and Surgery Annual Conference

WESTFORD, Mass., April 2 /PRNewswire-FirstCall/ -- Cynosure, Inc. (Nasdaq: CYNO) today announced the presentation of positive efficacy data from two post-marketing studies that demonstrate the skin-tightening and tissue-shrinking effects of the Company's Smartlipo MPX(TM) laser lipolysis workstation. The studies are being presented at the 2009 American Society for Laser Medicine and Surgery (ASLMS) Annual Conference, which is taking place April 1-5 at the Gaylord National Resort & Convention Center near Washington, D.C.

A randomized, blinded study, conducted by Barry DiBernardo, M.D., Medical Director of New Jersey Plastic Surgery & MedNet Technologies, Inc., compared Smartlipo MPX workstation against liposuction for their ability to improve skin elasticity and tighten tissue. A total of 10 women received a single treatment with liposuction on one side of the abdomen and the dual-wavelength Smartlipo MPX on the other. Skin shrinkage was evaluated through photographic imaging and measurement of temporary ink markings. Skin tightening was evaluated with the use of an elasticity device. Measurements were taken at baseline and at one and three months post-treatment.

At one and three months, skin treated with Smartlipo MPX had a statistically significant higher skin shrinkage ratio than skin treated with liposuction only, Dr. DiBernardo reported. Of the nine patients who were fully evaluated, eight, or 89%, had an average of 54% greater shrinkage at three months on the Smartlipo MPX side than the liposuction side. The study also showed a statistically significant difference in skin tightening. At three months, the average improvement in skin tightening was 62% with Smartlipo MPX compared with a 5% improvement on the side treated with liposuction.

'This is the first head-to-head quantitative study comparing the efficacy of the Smartlipo MPX workstation with that of liposuction, and the first study to illustrate the effects of subdermal applications of laser energy on skin laxity and tissue tightening,' Dr. DiBernardo said. 'The ability of Smartlipo MPX to lipolyze and remove unwanted areas of fat already has been clearly established. The results of our study now demonstrate that laser lipolysis can achieve greater skin tightening and skin shrinkage than liposuction alone.'

Smartlipo MPX also was the focus of a post-marketing study conducted by Bruce Katz, M.D., Clinical Professor of Dermatology at The Mount Sinai School of Medicine and Director of the Juva Skin & Laser Center in New York. A total of 20 subjects with unwanted localized areas of fat and skin laxity were treated with Smartlipo MPX. In a subset of five patients, skin tightening through surface area reduction was measured with the use of temporary tattoo markings, and biopsies were performed before the procedure, as well as three days and one month post-treatment, to determine the presence of new collagen markers.

In addition to a reduction in localized fat deposits, the study demonstrated new collagen formation and an 18% decrease in skin surface area. 'The data clearly indicate that Smartlipo MPX not only has a significant skin tightening effect, but also contributes to new collagen formation that is vital to skin tonicity,' Dr. Katz said.