Acusphere, Inc. (ACUS.PK) today announced that it has prepaid its equipment loans with Oxford Finance Corporation and Massachusetts Development Finance Agency. These transactions, in combination with the previously disclosed prepayment in full of General Electric Capital Corporation debt, represent total debt reduction of $3.8 million. After such prepayments, the Company has approximately $2.4 million in unaudited cash which is expected to fund operations to the end of the third quarter of 2009 based on the current operating plan.

The Company continues to discuss its New Drug Application (NDA) with the U.S. Food & Drug Administration (FDA) for its lead product candidate, Imagify™ (Perflubutane Polymer Microspheres) for Injectable Suspension, a Perfusion Stress Echo imaging agent targeted for use in detecting coronary artery disease. The Company previously announced that it had received a complete response from the FDA for Imagify in February 2009, FDA’s target date under the Prescription Drug User Fee Act (PDUFA). The response was largely consistent with the feedback received at the Advisory Committee meeting in December 2008, and discussions that continued with FDA in January 2009. In general, FDA’s response stated that additional clinical work would be required to support approval. Discussions with FDA continue regarding the design of the clinical program.

About Acusphere, Inc.

Acusphere is a specialty pharmaceutical company that develops new drugs and improved formulations of existing drugs using its proprietary microsphere technology. We are focused on developing proprietary drugs that can offer significant benefits such as improved safety and efficacy, increased patient compliance, greater ease of use, expanded indications or reduced cost. Our lead product candidate, Imagify^TM (Perflubutane Polymer Microspheres) for Injectable Suspension, is a cardiovascular drug for the detection of coronary artery disease, the leading cause of death in the United States, for which a New Drug Application (NDA) was submitted to the U.S. Food & Drug Administration (FDA) in April 2008 and filed in June 2008. Imagify and the Company's other product candidates were created using proprietary technology that enables Acusphere to control the porosity and size of nanoparticles and microspheres in a versatile manner that allows them to be customized to address the delivery needs of a variety of drugs.