SOUTH SAN FRANCISCO, CA -- (Marketwire) -- 08/24/09 -- Cytokinetics, Incorporated (NASDAQ: CYTK) announced today that data relating to two Phase IIa clinical trials evaluating omecamtiv mecarbil (formerly CK-1827452), one in stable heart failure patients and one in patients with ischemic cardiomyopathy and angina, are scheduled to be presented in two poster presentations at the European Society of Cardiology Congress 2009, to be held August 29 - September 2, 2009 at the Fira Gran Via Plaza Europa in Barcelona, Spain.

Poster Presentations

Abstract #84776: "Echocardiographic Detection of Increases in Ejection Fraction in Patients with Heart Failure Receiving the Selective Cardiac Myosin Activator, CK-1827452" is scheduled to be displayed on Monday, August 31, 2009 from 8:30 AM - 12:30 PM Central European Summer Time (CEST) in Zone 3. The poster will be moderated by Andrew Wolff, MD, FACC, Senior Vice President of Clinical Research and Development and Chief Medical Officer, Cytokinetics, Inc., South San Francisco, California.

Abstract #84636: "Phase II Safety Study Evaluating the Novel Cardiac Myosin Activator, CK-1827452, in Patients with Ischemic Cardiomyopathy and Angina" is scheduled to be displayed on Monday, August 31, 2009 from 8:30 AM - 12:30 PM CEST in Zone 3. The poster will be moderated by Barry H. Greenberg, MD, Director, Advanced Heart Failure Treatment Program, University of California, San Diego Medical Center and Chair of the Safety Review Committee for this clinical trial.

About Cytokinetics

Cytokinetics is a clinical-stage biopharmaceutical company focused on the discovery and development of novel small molecule therapeutics that modulate muscle function for the potential treatment of serious diseases and medical conditions. Cytokinetics' cardiac muscle contractility program is focused on cardiac muscle myosin, a motor protein essential to cardiac muscle contraction. Cytokinetics' lead compound from this program, omecamtiv mecarbil (formerly CK-1827452), a novel small molecule cardiac muscle myosin activator, is in Phase II clinical trials for the potential treatment of heart failure. In May 2009, Amgen Inc. exercised an option to obtain an exclusive worldwide (excluding Japan) license to develop and commercialize omecamtiv mecarbil and related compounds. Under the terms of the companies' agreement, Amgen has assumed responsibility for development and commercialization of omecamtiv mecarbil and related compounds, at its expense, subject to specified development and commercialization participation rights of Cytokinetics. In June 2009, Cytokinetics initiated a Phase I clinical trial of CK-2017357, a fast skeletal muscle troponin activator, in healthy volunteers in the United States.