Form 3 OSCIENT PHARMACEUTICALS For: Nov 25 Filed by: GLG Market Neutral Fund (10K)

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

GLG Partners LP

(Last)

(First)

(Middle)

1 CURZON STREET,

(Street)

LONDON

W1J 5HB

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
11/25/2008

3. Issuer Name and Ticker or Trading Symbol
OSCIENT PHARMACEUTICALS CORP [OSCI]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

Director	X	10% Owner
Officer (give title below)		Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common stock, par value $0.10 (the "Common Stock")	859,539	I ⁽¹⁾ ⁽²⁾	See Footnotes ⁽¹⁾ ⁽²⁾

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Excercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Excercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
12.50% Convertible Guaranteed Senior Notes	11/25/2008	01/15/2011	Common Stock	3,272,727	$ 1.1	I ⁽¹⁾ ⁽²⁾	See Footnotes ⁽¹⁾ ⁽²⁾

Explanation of Responses:

1. GLG Partners LP, an English limited partnership, acts as the investment manager for GLG Market Neutral Fund, which owns 859,539 shares of Common Stock and $3,600,000 aggregate principal amount of 12.50% Convertible Guaranteed Senior Notes due 2011, convertible into 3,272,727 shares of Common Stock.

2. GLG Partners LP, an English limited partnership, acts as the investment manager of GLG Market Neutral Fund and may be deemed, as of the date hereof, to be the beneficial owner of the Issuer's securities or derivative securities held by GLG Market Neutral Fund. GLG Partners Limited, an English limited company, is the general partner of GLG Partners LP. GLG Partners, Inc. indirectly wholly owns GLG Partners Limited. GLG Partners LP, GLG Partners Limited and GLG Partners, Inc. do not hold directly any of the Issuer's securities or derivative securities with respect thereto, and disclaim any beneficial ownership of any of the Issuer's securities reported or excluded herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended, except for their pecuniary interest therein.

	GLG Partners LP, By: GLG Partners Limited as its General Partner, By: /s/ Victoria Parry, Senior Legal Counsel of GLG Partners LP	01/15/2009
	** Signature of Reporting Person	Date
	GLG Partners LP, By: GLG Partners Limited as its General Partner, By: /s/ Emmanuel Roman, Managing Director	01/15/2009
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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                             Joint Filer Information

Name: GLG Market Neutral Fund

Address:  c/o GLG Partners LP
           1 Curzon Street
           London W1J 5HB
           England

Designated Filer: GLG Partners LP

Issuer and Ticker Symbol: Oscient Pharmaceuticals Corporation (OSCI)

Date of Event Requiring Statement: November 25, 2008

Signature:


By: GLG Partners LP,
As its Investment Manager



     By: /s/ Victoria Parry
         ------------------------------------
         Name:  Victoria Parry
         Title:  Senior Legal Counsel of GLG Partners LP

     By: /s/ Emmanuel Roman
         ------------------------------------
         Name:  Emmanuel Roman
         Title:  Managing Director







                             Joint Filer Information

Name: GLG Partners Limited

Address:  c/o GLG Partners LP
           1 Curzon Street
           London W1J 5HB
           England

Desginated Filer: GLG Partners LP

Issuer and Ticker Symbol: Oscient Pharmaceuticals Corporation (OSCI)

Date of Event Requiring Statement: November 25, 2008

Signature:

     By: /s/ Victoria Parry
         -------------------------------
         Name:  Victoria Parry
         Title:  Senior Legal Counsel of GLG Partners LP

     By: /s/ Emmanuel Roman
         -------------------------------
         Name:  Emmanuel Roman
         Title:  Managing Director





                             Joint Filer Information

Name: GLG Partners, Inc.

Address:  390 Park Avenue, 20th Floor
              New York, NY 10022

Designated Filer: GLG Partners LP

Issuer and Ticker Symbol: Oscient Pharmaceuticals Corporation (OSCI)

Date of Event Requiring Statement: November 25, 2008


Signature:


     By: /s/ Alejandro R. San Miguel
         ---------------------------------
         Name: Alejandro R. San Miguel
         Title: General Counsel and Corporate Secretary

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