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FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Frapaise Francois-Xavier

(Last)(First)(Middle)
10110 SORRENTO VALLEY ROAD, SUITE C

(Street)
SAN DIEGOCA92122

(City)(State)(Zip)
2. Issuer Name and Ticker or Trading Symbol
OPTIMER PHARMACEUTICALS INC [OPTR]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
Officer (give title below)Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
02/19/2009
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeVAmount(A) or (D)Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (right to buy) $ 10.85 02/19/2009 A  120,000   (1)02/19/2009 Common Stock 120,000 $ 0 120,000 D  
Explanation of Responses:
1. 1/4th of the shares subject to the option shall vest on the year year anniversary of the vesting commencement date, and 1/48 of the total shares shall vest each month thereafter, subject to optionee continuing to be a service provider on each such date.
John D. Prunty, attorney-in-fact02/23/2009
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

OPTIMER PHARMACEUTICALS, INC.
POWER OF ATTORNEY
SECURITIES LAW COMPLIANCE
The undersigned, as a Section 16 reporting person of 
Optimer Pharmaceuticals, Inc. (the Company), hereby 
constitutes and appoints John D. Prunty and Tessie M. Che, 
and each of them, the undersigned s true and lawful 
attorney in fact to: 
(1) execute for and on behalf of the undersigned, in the 
undersigneds capacity as an officer and or director of 
the Company, Form ID, Form 3, Form 4 and Form 5 (including 
any amendments thereto) in accordance with Section 16(a) 
of the Securities Exchange Act of 1934, as amended, and 
the rules thereunder;
(2) do and perform any and all acts for and on behalf of 
the undersigned which may be necessary or desirable to 
complete the execution of any such Form ID, Form 3, Form 4 
and Form 5 and the timely filing of any such form with the 
United States Securities and Exchange Commission and any 
other authority; and
(3) take any other action of any type whatsoever in 
connection with the foregoing which, in the opinion of 
such attorney in fact, may be of benefit to, to the best 
interest of, or legally required by, the undersigned, it 
being understood that the documents executed by such 
attorney-in fact on behalf of the undersigned pursuant to 
this Power of Attorney shall be in such form and shall 
contain such terms and conditions as such attorney in fact 
may approve in his or her discretion.
The undersigned hereby grants to each such attorney in
fact full power and authority to do and perform all and 
every act and thing whatsoever requisite, necessary and 
proper to be done in the exercise of any of the rights and 
powers herein granted, as fully to all intents and 
purposes as the undersigned might or could do if 
personally present, with full power of substitution or 
revocation, hereby ratifying and confirming all that such 
attorney in fact, or his or her substitute or substitutes, 
shall lawfully do or cause to be done by virtue of this 
power of attorney and the rights and powers herein 
granted. 
The undersigned acknowledges that the foregoing attorneys-
in-fact, in serving in such capacity at the request of the 
undersigned, are not assuming, nor is the Company 
assuming, any of the undersigned's responsibilities to 
comply with Section 16 of the Securities Exchange Act of 
1934, as amended.
This Power of Attorney shall remain in full force and 
effect until the undersigned is no longer required to file 
Form ID, Form 3, Form 4 and Form 5 with respect to the 
undersigneds holdings of and transactions in securities 
issued by the Company, unless earlier revoked by the 
undersigned in a signed writing delivered to the foregoing 
attorneys in fact.
IN WITNESS WHEREOF, the undersigned has caused this Power 
of Attorney to be executed as of this 19 day of February, 
2009.

Signature: /s/Francois-Xavier Frapaise
Print Name:  Francois-Xavier Frapaise
-2-
POA form for Frapaise 1-29-09.docx

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