| Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned |
1.Title of Security (Instr. 3) | 2. Transaction Date (Month/Day/Year) | 2A. Deemed Execution Date, if any (Month/Day/Year) | 3. Transaction Code (Instr. 8) | 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) | 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) | 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) | 7. Nature of Indirect Beneficial Ownership (Instr. 4) |
| Code | V | Amount | (A) or (D) | Price |
|
Common Stock
| 08/19/2009 | | M | |
29,100
| A | $
0.58
|
29,100
|
D
| |
|
Common Stock
| 08/19/2009 | | S | |
7,348
| D | $
2.8
|
21,752
|
D
| |
|
Common Stock
| 08/19/2009 | | S | |
3,337
| D | $
2.81
|
18,415
|
D
| |
|
Common Stock
| 08/19/2009 | | S | |
7,570
| D | $
2.82
|
10,845
|
D
| |
|
Common Stock
| 08/19/2009 | | S | |
5,388
| D | $
2.83
|
5,457
|
D
| |
|
Common Stock
| 08/19/2009 | | S | |
5,457
| D | $
2.84
|
0
|
D
| |
|
Common Stock
| 08/20/2009 | | M | |
20,000
| A | $
0.58
|
20,000
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
6,507
| D | $
2.83
|
13,493
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
700
| D | $
2.84
|
12,793
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
3,600
| D | $
2.85
|
9,193
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
2,959
| D | $
2.86
|
6,234
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
5,075
| D | $
2.87
|
1,159
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
986
| D | $
2.88
|
173
|
D
| |
|
Common Stock
| 08/20/2009 | | S | |
173
| D | $
2.82
|
0
|
D
| |
|
Common Stock
| | | | | | | |
49,550
|
I
|
by Trust
|
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities) |
1. Title of Derivative Security (Instr. 3) | 2. Conversion or Exercise Price of Derivative Security | 3. Transaction Date (Month/Day/Year) | 3A. Deemed Execution Date, if any (Month/Day/Year) | 4. Transaction Code (Instr. 8) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) | 6. Date Exercisable and Expiration Date (Month/Day/Year) | 7. Title and Amount of Underlying Securities (Instr. 3 and 4) | 8. Price of Derivative Security (Instr. 5) | 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) | 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) | 11. Nature of Indirect Beneficial Ownership (Instr. 4) |
| Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares |
|
Incentive Stock Option (right to buy)
| $
0.58
| 08/19/2009 | | M | | |
29,100
| 09/28/1999 | 09/28/2009 |
Common Stock
|
29,100
|
$
0
|
20,000
|
D
| |
|
Incentive Stock Option (right to buy)
| $
0.58
| 08/20/2009 | | M | | |
20,000
| 09/28/1999 | 09/28/2009 |
Common Stock
|
20,000
|
$
0
|
0
|
D
| |
|
Incentive Stock Option (right to buy)
| $
0.58
| | | | | | | 11/14/2000 | 11/14/2010 |
Common Stock
|
172,413
| |
172,413
|
D
| |
|
Incentive Stock Option (right to buy)
| $
1.2
| | | | | | | 07/10/2002 | 07/10/2012 |
Common Stock
|
83,333
| |
83,333
|
D
| |
|
Incentive Stock Option (right to buy)
| $
1.2
| | | | | | | 05/21/2003 | 05/21/2013 |
Common Stock
|
75,000
| |
75,000
|
D
| |
|
Incentive Stock Option (right to buy)
| $
6.5
| | | | | | | 04/08/2004 | 03/08/2014 |
Common Stock
|
66,943
| |
66,943
|
D
| |
|
Incentive Stock Option (right to buy)
| $
6.59
| | | | | | | 04/11/2005 | 04/11/2015 |
Common Stock
|
15,154
| |
15,154
|
D
| |
|
Incentive Stock Option (right to buy)
| $
6.81
| | | | | | | 04/01/2007 | 03/14/2017 |
Common Stock
|
11,091
| |
11,091
|
D
| |
|
Incentive Stock Option (right to buy)
| $
7.15
| | | | | | | 03/01/2006 | 03/01/2016 |
Common Stock
|
18,464
| |
18,464
|
D
| |
|
Non-Qualified Stock Option (right to buy)
| $
1.2
| | | | | | | 07/10/2002 | 07/10/2012 |
Common Stock
|
161,254
| |
161,254
|
D
| |
|
Non-Qualified Stock Option (right to buy)
| $
6.5
| | | | | | | 04/08/2004 | 03/08/2014 |
Common Stock
|
19,557
| |
19,557
|
D
| |
|
Non-Qualified Stock Option (right to buy)
| $
6.59
| | | | | | | 04/11/2005 | 04/11/2015 |
Common Stock
|
69,846
| |
69,846
|
D
| |
|
Non-Qualified Stock Option (right to buy)
| $
6.81
| | | | | | | 04/01/2007 | 03/14/2017 |
Common Stock
|
88,909
| |
88,909
|
D
| |
|
Non-Qualified Stock Option (right to buy)
| $
7.15
| | | | | | | 03/01/2006 | 03/01/2016 |
Common Stock
|
131,536
| |
131,536
|
D
| |
| James H. Sabry, M.D., Ph.D. | 08/21/2009 |
| ** Signature of Reporting Person | Date |
| Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. |
| * If the form is filed by more than one reporting person, see Instruction 4(b)(v). |
| ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations
See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
|
| Note: File three copies of this Form, one of which must be manually signed. If space is insufficient,
see Instruction 6 for procedure. |
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