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FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Blum Robert I
(Last)(First)(Middle)
280 EAST GRAND AVENUE
(Street)
SOUTH SAN FRANCISCOCA94080
(City)(State)(Zip)
2. Issuer Name and Ticker or Trading Symbol
CYTOKINETICS INC [CYTK]		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
President & CEO
3. Date of Earliest Transaction (Month/Day/Year)
09/24/2009
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code
(Instr. 8)		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		7. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock 09/24/2009 M(1)  500 A$ 1.2 22,960 D  
Common Stock 09/24/2009 S(2)  500 D$ 4.62 22,460 D  
Common Stock         12,500 I by Trust 1 (3)
Common Stock         12,500 I by Trust 2 (4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date
(Month/Day/Year)		7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		11. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Incentive Stock Option (right to buy) $ 1.2 09/24/2009 M   500 07/10/2002(5)07/10/2012 Common Stock 500 $ 0 18,833 D  
Incentive Stock Option (right to buy) $ 0.58       01/14/2000(6)11/14/2010 Common Stock 12   12 D  
Incentive Stock Option (right to buy) $ 1.2       05/21/2003(7)05/21/2013 Common Stock 37,500   37,500 D  
Incentive Stock Option (right to buy) $ 1.85       03/26/2009(8)02/26/2019 Common Stock 50,333   50,333 D  
Incentive Stock Option (right to buy) $ 2       12/18/2003(9)12/18/2013 Common Stock 27,500   27,500 D  
Incentive Stock Option (right to buy) $ 3.37       03/29/2008(10)02/28/2018 Common Stock 8,334   8,334 D  
Incentive Stock Option (right to buy) $ 6.59       04/11/2005(11)04/11/2015 Common Stock 45,000   45,000 D  
Incentive Stock Option (right to buy) $ 6.81       04/01/2007(12)03/14/2017 Common Stock 22,806   22,806 D  
Incentive Stock Option (right to buy) $ 7.15       03/01/2006(13)03/01/2016 Common Stock 28,494   28,494 D  
Non-Qualified Stock Option (right to buy) $ 1.2       07/10/2002(5)07/10/2012 Common Stock 12,264   12,264 D  
Non-Qualified Stock Option (right to buy) $ 1.85       03/26/2009(8)02/26/2019 Common Stock 224,667   224,667 D  
Non-Qualified Stock Option (right to buy) $ 2       12/18/2003(9)12/18/2013 Common Stock 48,692   48,692 D  
Non-Qualified Stock Option (right to buy) $ 3.37       03/29/2008(10)02/28/2018 Common Stock 191,666   191,666 D  
Non-Qualified Stock Option (right to buy) $ 6.81       04/01/2007(12)03/14/2017 Common Stock 227,194   227,194 D  
Non-Qualified Stock Option (right to buy) $ 7.15       03/01/2006(13)03/01/2016 Common Stock 71,506   71,506 D  
Explanation of Responses:
1. The exercise reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 13, 2009.
2. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 13, 2009.
3. Shares held by The Bridget Blum 2003 Irrevocable Trust.
4. Shares held by The Brittany Blum 2003 Irrevocable Trust.
5. When the ISO and NQ dated 07/10/02 are combined for a total grant of 150,000 shares, the option is immediately exercisable upon grant and shall vest as to 2,500 shares on 04/15/02 and the balance of 147,500 divided into equal monthly installments thereafter such that the option shall be 100% vested on 03/15/07.
6. This option is immediately exercisable upon grant and shall vest as to 25,000 shares on 11/14/00 and the balance of 87,500 divided into equal monthly installments thereafter such that the option shall be 100% vested on 11/14/05.
7. This option is immediately exercisable upon grant and shall vest as to 781 shares on 04/01/03 and the balance of 36,719 divided into equal monthly installments thereafter such that the option shall be 100% vested on 03/01/07.
8. When the ISO and NQ dated 02/26/2009 are combined for a total grant of 275,000 shares, the option shall vest and become exercisable as to 5,729 shares on 03/26/09 and the balance of 269,271 divided into equal monthly installments thereafter such that the option shall be 100% vested on 02/26/13.
9. When the ISO and NQ dated 12/18/03 are combined for a total grant of 141,925 shares, the option is immediately exercisable upon grant and shall vest as to 2,365 shares on 01/18/04 and the balance of 139,560 divided into equal monthly installments thereafter such that the option shall be 100% vested on 12/18/08.
10. When the ISO and NQ dated 02/29/2008 are combined for a total grant of 200,000 shares, the option shall vest and become exercisable as to 4,166 shares on 03/29/08 and the balance of 195,834 divided into equal monthly installments thereafter such that the option shall be 100% vested on 02/29/12.
11. This option shall vest and become exercisable as to 45,000 shares divided into equal monthly installments such that the option shall be 100% vested on 03/01/2009.
12. When the ISO and NQ dated 03/14/2007 are combined for a total grant of 250,000 shares, the option shall vest and become exercisable as to 5,208 shares on 04/01/07 and the balance of 244,792 divided into equal monthly installments thereafter such that the option shall be 100% vested on 03/01/11.
13. When the ISO and NQ dated 03/01/2006 are combined for a total grant of 100,000 shares, the option shall vest and become exercisable as to 100,000 shares divided into equal monthly installments such that the option shall be 100% vested on 03/01/2010.
Robert I. Blum09/25/2009
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

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